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American Epilepsy Society Study shows CBD can be best treatment for epilepsy

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dravets syndrome cbd epilepsyA recent study by the American Epilepsy Society shows that the cannabis component CBD is a safe and viable treatment for treatment resistant epilepsy.

Despite numerous states legislating for medical marijuana, the DEA refuses to remove cannabis from the Schedule 1 drug list, claiming it has no therapeutic value. This Schedule 1 classification means that scientists in the US struggle to study the possible clinical applications of the plant. And yet … in the areas where medical marijuana is allowed, one curative application stands out as being majorly successful and life changing. Children suffering from severe epileptic conditions  such as Dravet’s Syndrome faced a life-expectancy of less than ten years, with the effects of multiple fits exponentially disabling them. Standard medical treatments did little to alleviate these conditions: but the discovery of “Charlotte’s Web” strain in Colorado, a high CBD, low THC cannabis strain made into an medical cannabis oil, did. Hundreds of parents flocked to areas like Colorado, and their stories reveal a hugely high success rate, with fits almost completely stopped.

Imagine the pain of being a parent to a child suffering such extreme torture, and knowing that there exists a successful treatment but your government agency refuses to acknowledge the weight of proof provided by anecodotal evidence – and at the same time, prevents science from researching this treament.

Read a mother’s story: Dravet’s Syndrome and high CBD here 

That’s why this study by the American Epilepsy Society is so important. Conducted by a reputable agency concerned with promoting research and cannabis oil epilepsyeducation for professionals working with epilepsy, its not shared social media of emotive memes but an impartial investigation of whether, and how, cannabidiol works.

But wait – I thought you said scientists found it difficult to study medical marijuana in the USA thanks to the DEA’s Schedule 1 classification of cannabis?

That;s still true. The reason why researchers were able to analyse the role of CBD in allieviating epilepsy is because they weren’t using cannabis itself. Instead they investigated the potential of EPIDIOLEX, a “proprietary oral solution of pure plant-derived cannabidiol, or CBD” produced by GW Pharmaceuticals. In other words: its OK to use cannabis if it comes from a drug company. 

We have to ask ourselves: how long can governments deny that medical marijuana works in the face of increasing evidence? And if drug companies produce medications that we can grow and make ourselves (at much lower costs) how long can it be illegal?

 

 

EFFICACY AND SAFETY OF EPIDIOLEX (CANNABIDIOL) IN CHILDREN AND YOUNG ADULTS WITH TREATMENT-RESISTANT EPILEPSY:

Children and young adults with TRE in an expanded access compassionate use program for CBD were enrolled in a prospective observational study. During the 4 week baseline, parents/caregivers kept prospective seizure diaries of all countable motor seizure types. Patients received a highly standardized pharmaceutical plant-derived, purified CBD. (Epidiolex: GW Pharma), at a gradually increasing dose from 2-5 mg/kg/day until intolerance occurred or a maximum dose of 25 mg/kg/day was achieved. Patients were seen at regular intervals of 2-4 weeks during the initial 12 weeks of therapy. Testing for hematologic, liver, kidney function and AED levels was performed at baseline, and after 4, 8 and 12 weeks of CBD therapy.
261 patients received at least 3 months of treatment and had available data at last group data collection (136 (52%) were male; average age 11.8 years, range 4 months-41 years; average weight 38 kg; range 6.4-127). The most common diagnoses were DS (44; 17%) and LGS (40; 15%). The average # of concomitant AEDs was 3.0. After 3 months of therapy, the median overall seizure frequency reduction was 45.1% in all patients and 62.7% in DS patients. For LGS patients, the median reduction of atonic seizures from baseline was 71.1%. Among all patients, 47% had a ≥50% reduction in seizures. Seizure-freedom at 3 months occurred in 9% of patients and 13% of DS patients. Clobazam co-therapy was associated with a higher rate of treatment response (≥50% convulsive seizure reduction): 57% v. 39%; this may reflect elevations in the desmethyl clobazam metabolite. Safety data from 313 patients representing 180 patient years was available at 16 sites. Adverse events in ≥10% of patients included somnolence (23%), diarrhea (23%), fatigue (17%), decreased appetite (17%), convulsions (17%) and vomiting (10%). 14 patients (4%) had an adverse event leading to discontinuation of CBD. 36 patients (12%) withdrew primarily due to lack of efficacy. Serious Adverse Events (SAEs) were reported in 106 patients (34%), including 7 deaths, none of which were considered treatment-related. 16 patients (5%) had SAEs that were considered treatment-related, including altered liver enzymes (4 pts; all were also on valproate and clobazam), status epilepticus/convulsion (4), diarrhea (4), decreased weight (3), thrombocytopenia (1), and others.
These results from an uncontrolled study support the animal studies and prior reports showing that CBD may be a promising treatment for TRE and it is generally well-tolerated in doses up to 25mg/kg/day. Epidiolex is now being investigated in randomized controlled studies in DS and LGS.

taken from the American Epilepsy Society 

Please sign: this petition on Change – a mother from Northern Ireland is joyful to have used cannabis to treat her son – but now finds herself a cannabis refugee, unable to return home for fear of prosecution:

sign here

The post American Epilepsy Society Study shows CBD can be best treatment for epilepsy appeared first on Growers Guide to Cannabis.


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